The Ketohexokinase (KHK) Antibody (C-term) from MyBioSource.com is a Rabbit Polyclonal antibody to Fructokinase, Ketohexokinase, and KHK. This antibody recognizes Human, and Mouse antigen. The Ketohexokinase (KHK) Antibody (C-term) has been validated for the following applications: ELISA, and Western Blot.
Description
Ketohexokinase (KHK), or fructokinase, catalyzes conversion of fructose to fructose-1-phosphate. Splice variant 1 is the highly active form found in liver, renal cortex, and small intestine, while splice variant 2 is the lower activity form found in most other tissues. KHK, like glucokinase (GCK) and glucokinase regulator (GCKR), is present in both liver and pancreatic islets. The inhibition of GCK by GCKR is blocked by binding of fructose-1-phosphate to GCKR. The chromosomal proximity of the metabolically connected GCKR and KHK genes has a genetic linkage in type 2 diabetes. Fructosuria, or hepatic fructokinase deficiency, is a benign, asymptomatic defect of intermediary metabolism associated with heterozygosity for G50R and A43T mutations in KHK